6 Best Computer Mice for Arthritis in 2026

The Lift is the most carefully shaped upright mouse in this group. Its body stands at 57 degrees, so the forearm turns toward a handshake position instead of lying flat with the palm down. The surface has a soft texture that grips lightly, and a thumb rest sits where the thumb naturally lands, which means you do not have to hold the mouse up with a pinch. You can connect through Bluetooth or the included Logi Bolt USB-A receiver.

The maker aims the Lift at small to medium hands, and that matters for comfort. A body that is too tall for a small palm makes the fingers curl and tire, while this one lets the hand settle without stretching. The downside is the learning curve, since an upright mouse takes a few days to feel normal, and it is built for the right hand, so left-handed users should look elsewhere. Expect some practice before clicks feel automatic.

In daily ownership the Lift needs very little attention. There are no cables to untangle, setup is a few seconds, and the shape stays comfortable across long sessions of reading or email. Next to the Logitech Ergo M575S it keeps the familiar motion of sliding across a desk, whereas the trackball stays put. Next to the UGREEN it feels more polished and more compact, which is why it takes the top spot here for most buyers.

The M575S removes the biggest source of motion in mouse use, which is dragging the whole hand and arm across the desk. You rest your palm on the sculpted shell and roll a ball with your thumb, so the cursor moves while the wrist stays still. The maker says it was developed with ergonomics experts, and the shape supports the hand so the fingers can relax. Three buttons can be customized, and you can pair it over Bluetooth or the included Logi Bolt receiver.

The tradeoff is that thumb control is a different skill. Fine tasks like selecting a single letter feel clumsy for the first week, and some people find the thumb tires if they roll it constantly. It also suits tight desks very well, because the whole device sits in one spot, so it is a smart choice when elbow room is limited. It runs on an AA battery rather than an internal rechargeable cell, which is easy for some buyers and a chore for others.

As an ownership matter, the ball lifts out for cleaning, and dust around it should be wiped off every few weeks. Against the Lift, the Ergo M575S asks for less arm travel but more thumb work. If your shoulders or wrists ache from sliding a mouse, this is the better answer. If your thumb is the sore spot, the vertical designs are the safer bet.

UGREEN gives you the vertical handshake shape with quiet clicks, which is a combination that suits people who prefer a light touch. The buttons are described as silent, so each press makes less noise and feels softer than the sharp tick of a budget mouse. There are five buttons, including ones for moving back and forward through web pages, and four DPI steps of 1000, 1600, 2000 and 4000 let you slow the cursor down for careful aiming.

Connection is flexible. Bluetooth and a 2.4G receiver both work, and the mouse can remember up to three devices, so you can move between a laptop and a tablet without re-pairing. The caution is that it is a larger upright body than the Lift, so very small hands may stretch to reach the side button. The finish is also plain, with fewer touches such as a dedicated rest for the thumb.

Ownership is simple, since you charge or replace power as the listing describes and otherwise leave it alone. Compared with the TECKNET, the UGREEN has fewer DPI steps but a cleaner, more compact set of options. That restraint is helpful, because fewer settings mean fewer ways to accidentally change the cursor speed and get confused by it.

The TECKNET is the vertical option for people who move between several computers during the day. It pairs through Bluetooth and a 2.4GHz USB-A receiver, and one button hops among three devices. Six DPI levels reach as high as 4800, which is far more speed than ordinary browsing needs, but the lower steps are useful because a slower cursor lets you aim without tiny, precise hand motion.

The listing describes the buttons as quiet, so clicks are soft enough for a library or a sleeping household. The compromise is polish. The shell is functional rather than refined, and it lacks the thumb rest and gentle texture of the Lift. Buyers who press hard or hold the mouse tightly may notice the body less supportive over a long day, so test it with a light grip first.

Day to day it is easy to live with. You pair it once, and then a press of the switch button moves it to the next device. Next to the UGREEN it offers more speed steps, and next to the JYKEYMOUT it can reach a third device. If you juggle a desktop, a laptop and a tablet, that extra slot is the reason to pick it.

The Anker is the easiest vertical mouse to understand. It uses a 2.4G USB receiver, so there is no Bluetooth pairing to fumble with, and you plug it in and begin. Three DPI choices of 800, 1200 and 1600 are sensible for everyday screens, and the next and previous buttons let you move through web pages without reaching for the keyboard, which cuts down on small hand movements.

Its limits are plain too. It has no Bluetooth, so it needs a free USB-A port, and a laptop that only has USB-C will need an adapter. It talks to just one computer at a time. The shape follows the right-hand vertical idea, but it does not offer the Lift's thumb rest or the multi-device flexibility of the TECKNET, so it is a basic tool rather than a flexible one.

That plainness is its value. A person who uses one desktop, never travels with the mouse and dislikes menus will find the Anker comfortable and uncomplicated. Against the JYKEYMOUT it gives up Bluetooth and a rechargeable battery, but gains a simpler start. Keep the receiver in the port, and the mouse is ready whenever you sit down.

The JYKEYMOUT combines a rechargeable battery with two connection modes, which removes the small job of changing batteries. One device can run on Bluetooth while another uses the 2.4G receiver, so the mouse serves a laptop and a desktop without re-pairing. DPI steps of 1000, 1200 and 1600 sit in the comfortable range for everyday screens, and the vertical shape follows the handshake posture for the right hand.

The budget shows in the details. The finish is simpler than the Logitech Lift, and there is no dedicated thumb rest or soft touch surface. Since it charges rather than using replaceable cells, you must remember to plug it in now and then, and a dead mouse in the middle of a task is the price of forgetting. Two devices is also one fewer than the TECKNET.

For ownership, charging is occasional and quick to do, and the dual mode makes it handy for someone with one laptop and one desktop. Compared with the Anker it adds Bluetooth and a rechargeable cell, and compared with the Lift it gives up refinement for lower cost. It suits shoppers who want upright comfort without paying for premium touches.